Winter Sorrow

Alcoholism

Classification

Alcohol and Health

Short-term effects of alcohol

Long-term effects of alcohol

Alcohol and cardiovascular disease

Alcoholic liver disease

Alcoholic hepatitis

Alcohol and cancer

Alcohol and weight

Fetal alcohol syndrome

Fetal Alcohol Spectrum Disorder

Alcoholism

Blackout (alcohol-related amnesia)

Wernicke-Korsakoff syndrome

Recommended maximum intake

Wine and health

The definitions of alcoholism and related terminology vary significantly between the medical community, treatment programs, and the general public.

Medical definitions

The National Council on Alcoholism and Drug Dependence and The American Society of Addiction Medicine define alcoholism as “a primary, chronic disease characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking.” The DSM-IV (the dominant diagnostic manual in psychiatry and psychology) defines alcohol abuse as repeated use despite recurrent adverse consequences. It further defines alcohol dependence as alcohol abuse combined with tolerance, withdrawal, and an uncontrollable drive to drink. (See DSM diagnosis below.) Within psychology and psychiatry, alcoholism is the popular term for alcohol dependence.

Terminology

Many terms are applied to a drinker’s relationship with alcohol. Use, misuse, heavy use, abuse, addiction, and dependence are all common labels used to describe drinking habits, but the actual meaning of these words can vary greatly depending upon the context in which they are used. Even within the medical field, the definition can vary between areas of specialization. Because alcoholism is often used in a derogatory sense in politics and religion, the meanings of the words surrounding it are often used imprecisely.

Use refers to simple use of a substance. An individual who drinks any alcoholic beverage is using alcohol. Misuse, problem use, abuse, and heavy use refers to improper use of alcohol which may cause physical, social, or moral harm to the drinker.

Moderate Use is defined by The Dietary Guidelines for Americans as no more than two alcoholic beverages per day for men and no more than one alcoholic beverage per day for women.

Risk factors

About 40 percent of those who begin drinking alcohol before age 14 develop alcohol dependence, whereas only 10 percent of those who did not begin drinking until 20 years or older developed an alcohol problem in later life, although it should be born in mind that Correlation does not imply causation. Alcohol abuse during adolescence may lead to long-term changes in the brain which leaves them at increased risk of alcoholism in later years; genetic factors also influence age of onset of alcohol abuse and risk of alcoholism.

The age of onset of drinking as well as genetic factors are associated with an increased risk of the development of alcoholism. Individuals who have a pre-existing vulnerability to alcoholism are also more likely to begin drinking earlier than average. The risk taking behavior associated with adolescence promotes binge drinking. Age and genetic factors influence the risk of developing alcohol related neurotoxicity. Genetic traits which influence the risk of the development of alcoholism are associated with a family history of alcoholism. One published article has found that alcohol use at an early age may itself directly influence the risk of developing alcoholism via influencing the expression of genes which increase the risk of alcohol dependence. It has been hypothesized that this increased risk may be due to the highly sensitive developing adolescent brain which leads to modulating of the genetic state of the brain which in turn primes the adolescent for increased risk of alcohol dependence. About 40 percent of alcoholics were drinking excessively by late adolescence. Most alcoholics develop alcoholism during adolescence or young adulthood. Severe childhood trauma is also associated with an increased risk of alcohol or other drug problems. There is evidence that a complex mixture of genetic factors as well as environmental factors, e.g. stressful childhood events, influence the risk of the development of alcoholism. Genes which influence the metabolism of alcohol also influence the risk of alcoholism. Good peer and family support is associated with a reduced risk of alcoholism developing.

Signs and symptoms

Effects of long term alcohol misuse

Main article: Long-term effects of alcohol

Most significant of the possible long-term effects of ethanol. Additionally, in pregnant women, it causes fetal alcohol syndrome.

The primary effect of alcoholism is to encourage the sufferer to drink at times and in amounts that are damaging to physical health. The secondary damage caused by an inability to control one’s drinking manifests in many ways. Alcoholism also has significant social costs to both the alcoholic and their family and friends. Alcoholism can have adverse effects on mental health causing psychiatric disorders to develop. Approximately 18 percent of alcoholics commit suicide. Research has found that over fifty percent of all suicides are associated with alcohol or drug dependence. In adolescents the figure is higher with alcohol or drug misuse playing a role in up to 70 percent of suicides.

Physical health effects

The physical health effects associated with alcohol consumption may include cirrhosis of the liver, pancreatitis, epilepsy, polyneuropathy, alcoholic dementia, heart disease, increased chance of cancer, nutritional deficiencies, sexual dysfunction, and death from many sources. Severe cognitive problems are not uncommon in alcoholics. Approximately 10% of all dementia cases are alcohol related making alcohol the 2nd leading cause of dementia. Other adverse effects on physical health include an increased risk of developing cardiovascular disease, malabsorption, alcoholic liver disease, and cancer. Damage to the central nervous system and peripheral nervous system can occur from sustained alcohol consumption.

Mental health effects

Long term misuse of alcohol can cause a wide range of mental health effects. Alcohol misuse is not only toxic to the body but also to brain function and thus psychological well being can be adversely affected by the long-term effects of misuse. Psychiatric disorders are common in alcoholics, especially anxiety and depression disorders, with as many as 25% of alcoholics presenting with severe psychiatric disturbances. Typically these psychiatric symptoms caused by alcohol misuse initially worsen during alcohol withdrawal but with abstinence these psychiatric symptoms typically gradually improve or disappear altogether. Psychosis, confusion and organic brain syndrome may be induced by chronic alcohol abuse which can lead to a misdiagnosis of major mental health disorders such as schizophrenia. Panic disorder can develop as a direct result of long term alcohol misuse. Panic disorder can also worsen or occur as part of the alcohol withdrawal syndrome. Chronic alcohol misuse can cause panic disorder to develop or worsen an underlying panic disorder via distortion of the neurochemical system in the brain.

The co-occurrence of major depressive disorder and alcoholism is well documented. Among those with comorbid occurrences, a distinction is commonly made between depressive episodes that are secondary to the pharmacological or toxic effects of heavy alcohol use and remit with abstinence, and depressive episodes that are primary and do not remit with abstinence. Additional use of other drugs may increase the risk of depression in alcoholics. Depressive episodes with an onset prior to heavy drinking or those that continue in the absence of heavy drinking are typically referred to as “independent” episodes, whereas those that appear to be etiologically related to heavy drinking are termed “substance-induced”. There is a high rate of suicide in chronic alcoholics with the risk of suicide increasing the longer a person drinks. The reasons believed to cause the increased risk of suicide in alcoholics include the long-term abuse of alcohol causing physiological distortion of brain chemistry as well as the social isolation which is common in alcoholics. Suicide is also very common in adolescent alcohol abusers, with 1 in 4 suicides in adolescents being related to alcohol abuse.

Social effects

The social problems arising from alcoholism can be massive and are caused in part due to the serious pathological changes induced in the brain from prolonged alcohol misuse and partly because of the intoxicating effects of alcohol. Alcohol abuse is also associated with increased risks of committing criminal offences including child abuse, domestic violence, rapes, burglaries and assaults. Alcoholism is associated with loss of employment, which can lead to financial problems including the loss of living quarters. Drinking at inappropriate times, and behavior caused by reduced judgment, can lead to legal consequences, such as criminal charges for drunk driving or public disorder, or civil penalties for tortious behavior. An alcoholic’s behavior and mental impairment while drunk can profoundly impact those surrounding them and lead to isolation fromfamily and friends, possibly leading to marital conflict and divorce, or contributing to domestic violence. This can contribute to a loss of self-esteem and even lead to jail. Alcoholism can also lead to child neglect, with subsequent lasting damage to the emotional development of the alcoholic’s children, even after they reach adulthood.

Alcohol withdrawal

Main article: Alcohol withdrawal syndrome

Alcohol withdrawal differs significantly from most other drugs in that it can be directly fatal. For example it is extremely rare for heroin withdrawal to be fatal. When people die from heroin or cocaine withdrawal they typically have serious underlying health problems which are made worse by the strain of acute withdrawal. An alcoholic, however, who has no serious health issues, has a significant risk of dying from the direct effects of withdrawal if it is not properly managed. Sedative-hypnotic drugs such as barbiturates and benzodiazepines which have a similar mechanism of action to alcohol (which is also a sedative-hypnotic) also have a similar risk of causing death during withdrawal.

Alcohol’s primary effect is the increase in stimulation of the GABAA receptor, promoting central nervous system depression. With repeated heavy consumption of alcohol, these receptors are desensitized and reduced in number, resulting in tolerance and physical dependence. Thus when alcohol is stopped, especially abruptly, the person’s nervous system suffers from uncontrolled synapse firing. This can result in symptoms that include anxiety, life threatening seizures, delirium tremens and hallucinations, shakes and possible heart failure.

Acute withdrawal symptoms tend to subside after one to three weeks. Less severe symptoms (e.g. insomnia And Anxiety, anhedonia) may continue as part of a post withdrawal syndrome gradually improving with abstinence for a year or more. Withdrawal symptoms begin to subside as the body and central nervous system makes adaptations to reverse tolerance and restore GABA function towards normal. Other neurotransmitter systems are involved, especially glutamate and NMDA.

Diagnosis

Multiple tools are available to those wishing to conduct screening for alcoholism. Identification involves an objective assessment regarding the damage that imbibing alcohol does to the drinker’s life compared with the subjective benefits the drinker perceives from consuming alcohol. While there are many cases where an alcoholic’s life has been significantly and obviously damaged, there are always borderline cases that can be difficult to classify.

Addiction Medicine specialists have extensive training with respect to diagnosing and treating patients with alcoholism.

Screening

Several tools may be used to detect a loss of control of alcohol use. These tools are mostly self reports in questionnaire form. Another common theme is a score or tally that sums up the general severity of alcohol use.

The CAGE questionnaire, named for its four questions, is one such example that may be used to screen patients quickly in a doctor’s office.

Two “yes” responses indicate that the respondent should be investigated further. The questionnaire asks the following questions:

Have you ever felt you needed to Cut down on your drinking?

Have people Annoyed you by criticizing your drinking?

Have you ever felt Guilty about drinking?

Have you ever felt you needed a drink first thing in the morning (Eye-opener) to steady your nerves or to get rid of a hangover?

The CAGE questionnaire, has demonstrated a high effectiveness in detecting alcohol related problems; however, it has limitations in people with less severe alcohol related problems, white women and college students.

The Alcohol Dependence Data Questionnaire is a more sensitive diagnostic test than the CAGE test. It helps distinguish a diagnosis of alcohol dependence from one of heavy alcohol use.

The Michigan Alcohol Screening Test (MAST) is a screening tool for alcoholism widely used by courts to determine the appropriate sentencing for people convicted of alcohol-related offenses, driving under the influence being the most common.

The Alcohol Use Disorders Identification Test (AUDIT) is a screening questionnaire developed by the World Health Organization. This test is unique in that it has been validated in six countries and is used internationally. Like the CAGE questionnaire, it uses a simple set of questions – a high score earning a deeper investigation.

The Paddington Alcohol Test (PAT) was designed to screen for alcohol related problems amongst those attending Accident and Emergency departments. It concords well with the AUDIT questionnaire but is administered in a fifth of the time.

Genetic predisposition testing

Psychiatric geneticists John I. Nurnberger, Jr., and Laura Jean Bierut suggest that alcoholism does not have a single causencluding geneticut that genes do play an important role “by affecting processes in the body and brain that interact with one another and with an individual’s life experiences to produce protection or susceptibility.” They also report that fewer than a dozen alcoholism-related genes have been identified, but that more likely await discovery.

At least one genetic test exists for an allele that is correlated to alcoholism and opiate addiction. Human dopamine receptor genes have a detectable variation referred to as the DRD2 TaqI polymorphism. Those who possess the A1 allele (variation) of this polymorphism have a small but significant tendency towards addiction to opiates and endorphin releasing drugs like alcohol. Although this allele is slightly more common in alcoholics and opiate addicts, it is not by itself an adequate predictor of alcoholism, and some researchers argue that evidence for DRD2 is contradictory.

DSM diagnosis

The DSM-IV diagnosis of alcohol dependence represents one approach to the definition of alcoholism. In part this is to assist in the development of research protocols in which findings can be compared with one another. According to the DSM-IV, an alcohol dependence diagnosis is:

…maladaptive alcohol use with clinically significant impairment as manifested by at least three of the following within any one-year period: tolerance; withdrawal; taken in greater amounts or over longer time course than intended; desire or unsuccessful attempts to cut down or control use; great deal of time spent obtaining, using, or recovering from use; social, occupational, or recreational activities given up or reduced; continued use despite knowledge of physical or psychological sequelae.

Urine and blood tests

There are reliable tests for the actual use of alcohol, one common test being that of blood alcohol content (BAC). These tests do not differentiate alcoholics from non-alcoholics; however, long-term heavy drinking does have a few recognizable effects on the body, including:

Macrocytosis (enlarged MCV)1

Elevated GGT

Moderate elevation of AST and ALT and an AST: ALT ratio of 2:1.

High carbohydrate deficient transferrin (CDT)

However, none of these blood tests for biological markers are as sensitive as screening questionaires.

Prevention

Because alcohol use disorders are perceived as impacting society as a whole, World Health Organization, the European Union and other regional bodies, national governments and parliaments have formed alcohol policies in order to reduce the harm of alcoholism.

To combat the health, social and educational underachievement which results from alcohol or drug dependence targeting adolescents and young adults is regarded as an important step to reduce the harm of alcohol abuse. The age at which licit drugs of abuse such as alcohol can be purchased as well as banning or restricting advertising of alcohol has been recommended. Credible and evidence based educational drives in the mass media about the consequences of alcohol and other drug abuse has also been recommended. Guidelines for parents on alcohol and drug use during adolescence and targeting young people with mental health problems has also been suggested to prevent the harm of alcohol and other drug abuse.

Management

Treatments for alcoholism (antidipsotropic) are quite varied because there are multiple perspectives for the condition itself. Those who approach alcoholism as a medical condition or disease recommend differing treatments than, for instance, those who approach the condition as one of social choice.

Most treatments focus on helping people discontinue their alcohol intake, followed up with life training and/or social support in order to help them resist a return to alcohol use. Since alcoholism involves multiple factors which encourage a person to continue drinking, they must all be addressed in order to successfully prevent a relapse. An example of this kind of treatment is detoxification followed by a combination of supportive therapy, attendance at self-help groups, and ongoing development of coping mechanisms. The treatment community for alcoholism typically supports an abstinence-based zero tolerance approach; however, there are some who promote a harm-reduction approach as well.

Effectiveness

When considering the effectiveness of treatment options, one must consider the success rate based on those who enter a program, not just those who complete it. Since completion of a program is the qualification for success, success among those who complete a program is generally near 100%. It is also important to consider not just the rate of those reaching treatment goals but the rate of those relapsing. Results should also be compared to the roughly 5% rate at which people will quit on their own. A year after completing a rehab program, about a third of alcoholics are sober, an additional 40 percent are substantially improved but still drink heavily on occasion, and a quarter have completely relapsed.

Detoxification

Main article: Alcohol detoxification

Alcohol detoxification or ‘detox’ for alcoholics is an abrupt stop of alcohol drinking coupled with the substitution of drugs that have similar effects to prevent alcohol withdrawal.

Detoxification treats the physical effects of prolonged use of alcohol, but does not actually treat alcoholism. After detox is complete, relapse is likely without further treatment. These rehabilitations (or ‘rehabs’) may take place in an inpatient or outpatient setting.

Group therapy and psychotherapy

A regional service center for Alcoholics Anonymous.

After detoxification, various forms of group therapy or psychotherapy can be used to deal with underlying psychological issues that are related to alcohol addiction, as well as provide relapse prevention skills.

The mutual-help group-counseling approach is one of the most common ways of helping alcoholics maintain sobriety. Many organizations have been formed to provide this service. Alcoholics Anonymous was the first group, and has more members than all other programs combined. Some of the others include LifeRing Secular Recovery, Rational Recovery, SMART Recovery, and Women For Sobriety.

Rationing and moderation

Rationing and moderation programs such as Moderation Management and DrinkWise do not mandate complete abstinence. While most alcoholics are unable to limit their drinking in this way, some return to moderate drinking. A 2002 U.S. study by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) showed that 17.7% of individuals diagnosed as alcohol dependent more than one year prior returned to low-risk drinking. This group, however, showed fewer initial symptoms of dependency. A follow-up study, using the same subjects that were judged to be in remission in 2001-2002, examined the rates of return to problem drinking in 2004-2005. The study found abstinence from alcohol was the most stable form of remission for recovering alcoholics. A long-term (60 year) follow-up of two groups of alcoholic men concluded that “return to controlled drinking rarely persisted for much more than a decade without relapse or evolution into abstinence.”

Medications

A variety of medications may be prescribed as part of treatment for alcoholism.

Medications currently in use

Antabuse (disulfiram) prevents the elimination of acetaldehyde, a chemical the body produces when breaking down ethanol. Acetaldehyde itself is the cause of many hangover symptoms from alcohol use. The overall effect is severe discomfort when alcohol is ingested: an extremely fast-acting and long-lasting uncomfortable hangover. This discourages an alcoholic from drinking in significant amounts while they take the medicine. A recent 9-year study found that incorporation of supervised disulfiram and a related compound carbamide into a comprehensive treatment program resulted in an abstinence rate of over 50%.

Temposil (calcium carbimide) works in the same way as Antabuse, but is weaker and safer[citation needed].

Naltrexone is a competitive antagonist for opioid receptors, effectively blocking our ability to use endorphins and opiates. Alcohol causes the body to release endorphins, hence when naltrexone is in the body drinkers no longer get any pleasure from consuming alcohol. Naltrexone is used in two very different forms of treatment. The first treatment uses naltrexone to decrease cravings for alcohol and encourage abstinence. The other treatment, called pharmacological extinction, combines naltrexone with normal drinking habits in order to reverse the endorphin conditioning that causes alcohol addiction. This results in a reduced desire to drink that persists after naltrexone use is discontinued, as long as the patient always takes naltrexone before drinking.

Naltrexone comes in two forms. Oral naltrexone (originally but no longer available as the brand ReVia) is a pill that must be taken one hour before drinking to be effective. Vivitrol is a time-release formulation that is injected in the buttocks once a month.

Acamprosate (also known as Campral) is thought to stabilize the chemical balance of the brain that would otherwise be disrupted by alcoholism. The Food and Drug Administration (FDA) approved this drug in 2004, saying “While its mechanism of action is not fully understood, Campral is thought to act on the brain pathways related to alcohol abuse… Campral proved superior to placebo in maintaining abstinence for a short period of time…” The COMBINE study was unable to demonstrate efficacy for Acamprosate.

Experimental Medications

Many experimental medications are presently in clinical trials for the treatment of alcoholism. Promising results have been obtained with anticonvulsant drugs usually used to treat epilepsy.

Topiramate (brand name Topamax), a derivative of the naturally occurring sugar monosaccharide D-fructose, has been found effective in helping alcoholics quit or cut back on the amount they drink. In one study heavy drinkers were six times more likely to remain abstinent for a month if they took the medication, even in small doses. In another study, those who received topiramate had fewer heavy drinking days, fewer drinks per day and more days of continuous abstinence than those who received the placebo. Evidence suggests that topiramate antagonizes excitatory glutamate receptors, inhibits dopamine release, and enhances inhibitory gamma-aminobutyric acid function. A 2008 review of the effectiness of topiramate concluded that the results of published trials are promising, however at this time, data are insufficient to support using topiramate in conjunction with brief weekly compliance counseling as a first-line agent for alcohol dependence.

Medications which may worsen outcome

Benzodiazepines, whilst useful in the management of acute alcohol withdrawal, if used long-term cause a worse outcome in alcoholism. Alcoholics on chronic benzodiazepines have a lower rate of achieving abstinence from alcohol than those not taking benzodiazepines. This class of drugs are commonly prescribed to alcoholics for insomnia or anxiety management. Initiating prescriptions of Benzodiazepines or sedative-hypnotics in individuals in recovery has a high rate of relapse with one author reporting more than a quarter of people relapse after being prescribed sedative-hypnotics. Patients often mistakenly think that they are sober despite continuing to take benzodiazepines. Those who are long-term users of benzodiazepines should not be withdrawn rapidly, taper regimes of 612 months have been found to be the most successful, with reduced intensity of withdrawal.

Dual addictions

The AMA definition of alcoholism refers to a disease entity involving the compulsive use of alcohol despite social, physical and mental harm.[citation needed]. The DSM-IV definition of alcohol dependence refers to alcohol only, and DSM-IV uses sedative dependence to refer to the disease entity involving non-alcohol sedative agents.[citation needed]

Alcoholics may also require treatment for other psychotropic drug addictions. The most common dual addiction in alcohol dependence is a benzodiazepine dependence with studies showing 10 – 20% of alcohol dependent individuals having problems of dependence and/or misuse problems of benzodiazepines. Alcohol itself is a sedative-hypnotic and is cross-tolerant with other sedative-hypnotics such as barbiturates, benzodiazepines and the nonbenzodiazepines. Dependence on other sedative hypnotics such as zolpidem and zopiclone as well as opiates and illegal drugs is common in alcoholics. Dependence and withdrawal from sedative hypnotics, eg benzodiazepine withdrawal is similar to alcohol and can be medically severe and include the risk of psychosis and seizures if not managed properly. Benzodiazepine dependency requires careful reduction in dosage to avoid a serious benzodiazepine withdrawal syndrome and health consequences. Benzodiazepines have the problem of increasing cravings for alcohol in problem alcohol consumers. Benzodiazepines also increase the volume of alcohol consumed by problem drinkers.

Epidemiology

Disability-adjusted life year for alcohol use disorders per 100,000 inhabitants in 2002.

     no data      less than 50      50-150      150-250      250-350      350-450      450-550      550-650      650-750      750-850      850-950      950-1050      more than 1050

Total recorded yearly alcohol per capita consumption (15+), in litres of pure alcohol

Substance use disorders are a major public health problem facing many countries. “The most common substance of abuse/dependence in patients presenting for treatment is alcohol.” In the United Kingdom, the number of ‘dependent drinkers’ was calculated as over 2.8 million in 2001. The World Health Organization estimates that about 140 million people throughout the world suffer from alcohol dependence. In the United States and western Europe 10 to 20% of men and 5 to 10% of women at some point in their lives will meet criteria for alcoholism.

Within the medical and scientific communities, there is broad consensus regarding alcoholism as a disease state. For example, the American Medical Association considers alcohol a drug and states that “drug addiction is a chronic, relapsing brain disease characterized by compulsive drug seeking and use despite often devastating consequences. It results from a complex interplay of biological vulnerability, environmental exposure, and developmental factors (e.g., stage of brain maturity).”

Current evidence indicates that in both men and women, alcoholism is 50-60% genetically determined, leaving 40-50% for environmental influences.

A 2002 study by the National Institute on Alcohol Abuse and Alcoholism surveyed a group of 4,422 adults meeting the criteria for alcohol dependence and found that after one year, some met the authors’ criteria for low-risk drinking, even though only 25.5% of the group received any treatment, with the breakdown as follows:

25% still dependent

27.3% in partial remission (some symptoms persist)

11.8% asymptomatic drinkers (consumption increases chances of relapse)

35.9% fully recovered made up of 17.7% low-risk drinkers plus 18.2% abstainers.

In contrast, however, the results of a long term (60 year) follow-up of two groups of alcoholic men by George Vaillant at Harvard Medical School indicated that “return to controlled drinking rarely persisted for much more than a decade without relapse or evolution into abstinence.” Vaillant also noted that “return-to-controlled drinking, as reported in short-term studies, is often a mirage.”

History

Etymology

1904 advertisement describing alcoholism as a disease.

The term “alcoholism” was first used in 1849 by the Swedish physician Magnus Huss to describe the systematic adverse effects of alcohol.

In the United States, use of the word “alcoholism” was largely popularized by the founding and growth of Alcoholics Anonymous in 1935[citation needed]. AA’s basic text, known as the “Big Book,” describes alcoholism as an illness that involves a physical allergy:p.xxviii and a mental obsession.:p.23 Note that the definition of “allergy” used in this context is not the same as used in modern medicine. . The doctor and addiction specialist Dr. William D. Silkworth M.D. writes on behalf of AA that Alcoholics suffer from a “(physical) craving beyond mental control”.

A 1960 study by E. Morton Jellinek is considered the foundation of the modern disease theory of alcoholism. Jellinek’s definition restricted the use of the word “alcoholism” to those showing a particular natural history. The modern medical definition of alcoholism has been revised numerous times since then. The American Medical Association currently uses the word alcoholism to refer to a particular chronic primary disease.

A minority opinion within the field, notably advocated by Herbert Fingarette and Stanton Peele, argue against the existence of alcoholism as a disease. Critics of the disease model tend to use the term “heavy drinking” when discussing the negative effects of alcohol consumption.

Society and culture

The various health problems associated with long-term alcohol consumption are generally perceived as detrimental to society, for example, money due to lost labor-hours, medical costs, and secondary treatment costs. Alcohol use is a major contributing factor for head injuries, motor vehicle accidents, violence, and assaults. Beyond money, there is also the pain and suffering of the individuals besides the alcoholic affected. For instance, alcohol consumption by a pregnant woman can lead to Fetal alcohol syndrome, an incurable and damaging condition.

Estimates of the economic costs of alcohol abuse, collected by the World Health Organization, vary from one to six per cent of a country’s GDP. One Australian estimate pegged alcohol’s social costs at 24 per cent of all drug abuse costs; a similar Canadian study concluded alcohol’s share was 41 per cent.

A study quantified the cost to the UK of all forms of alcohol misuse as 18.520 billion annually (2001 figures).

Stereotypes

Depiction of a wino or town drunk

Stereotypes of alcoholics are often found in fiction and popular culture. The ‘town drunk’ is a stock character in Western popular culture.

Stereotypes of drunkenness may be based on racism or xenophobia, as in the depiction of the Irish as heavy drinkers.

Studies by social psychologists Stivers and Greeley attempt to document the perceived prevalence of high alcohol consumption amongst the Irish in America.

Alcohol-related crime

See also: Drug-related crime

This section may require cleanup to meet Wikipedia’s quality standards. Please improve this section if you can. (July 2009)

Of the adult US population, at least 75% are drinkers; and about 6% of the total group are alcoholics. In groups which are almost 100% drinkers, the alcoholism rate is about 8%. Many reports state that about 73% of felonies are alcohol-related. One survey shows that in about 67% of child-beating cases, 41% of forcible rape cases, 80% of wife-battering, 72% of stabbings, and 83% of homicides, either the attacker or the victim or both had been drinking.”

In film and literature

In modern times, the recovery movement has led to more realistic depictions of problems that stem from heavy alcohol use. Authors such as Charles R. Jackson and Charles Bukowski describe their own alcohol addiction in their writings. The disjointed narrative of Patrick Hamilton’s Hangover Square reflects the alcoholism of its central character. A famous depiction of alcoholism, and the psychology of an alcoholic, is in Malcolm Lowry’s widely acclaimed novel Under the Volcano, which details the final day of the British consul Geoffrey Firmin on the Day of the Dead in 1939 Mexico and his choice to continue his extreme alcohol consumption instead of returning to the wife he loves.

Films like Bad Santa, Barfly, Days of Wine and Roses, Ironweed, My Name Is Bill W., Withnail and I, Arthur, Leaving Las Vegas, When a Man Loves a Woman, Shattered Spirits and The Lost Weekend chronicle similar stories of alcoholism.

Women and alcoholism

Alcoholism has a higher prevalence among men, though in recent decades, the proportion of female alcoholics has increased. It is important to articulate the different biological and social ways alcoholism manifests in women in order to understand barriers to treatment and effective recovery strategies.

William Hogarth’s Gin Lane, 1751.

Biological differences and physiological effects

Biologically, women have symptom profiles from their alcohol use that differ in important ways from men. They experience a telescoping of physiological effects from alcohol use. Equal dosages of alcohol consumed by men and women generally result in women having higher blood alcohol concentrations (BACs). This can be attributed to many reasons, the main being that women have less body water than men. A given amount of alcohol, therefore becomes more highly concentrated in a woman’s body. Besides this fact, women also become more intoxicated, which is due to different hormone release.

Women develop long-term complications of alcohol dependence more rapidly than do alcoholic men. Additionally, women have a higher mortality rate from alcoholism than men. Examples of long term complications include brain, heart, and liver damage and an increased risk for breast cancer (see alcohol and breast cancer). Additionally, heavy drinking over time has been found to have a negative effect on reproductive functioning in women. This results in reproductive dysfunction such as anovulation, decreased ovarian mass, irregular menses, amenorrhea, luteal phase dysfunction, and early menopause.

Psychological and emotional effects

Psychiatric disorders are generally more prevalent among those with alcohol disorders. This is true for both men and women, however the disorders differ depending on gender. Women who have alcohol-use disorders often have co-occurring psychiatric diagnosis such as Major Depression, anxiety, panic disorder, bulimia, post-traumatic stress disorder (PTSD), or borderline personality disorder. Men with alcohol-use disorders more often have co-occurring diagnosis of narcissistic and antisocial personality disorders, bipolar disorder, schizophrenia, impulse disorders and attention deficit/ hyperactivity disorder.

Women with alcoholism are also more likely to have a history of physical or sexual assault, abuse and domestic violence than those in the general population. This trauma can lead to higher instances of PTSD, depression, anxiety, and a greater dependence on alcohol.

Societal barriers to treatment

Attitudes and social stereotypes about women and alcohol can create barriers to the detection and treatment of female alcohol abusers. Such beliefs stigmatize women who drink by characterizing them as “both generally and sexually immoral” or the “fallen women.” Fear of stigmatization may lead women to deny that they are suffering from a medical condition, to hide their drinking, and to drink alone. This pattern, in turn, leads family, physicians, and others to be less likely to suspect that a woman they know is an alcoholic.

In contrast, attitudes and social stereotypes about men and alcohol can lower barriers to the detection and treatment of male alcohol abusers. Such beliefs reward men who drink by characterizing them as “both generally and sexually moral” or the “risen men.” Reduced fear of stigma may lead men to admit that they are suffering from a medical condition, to publicly display their drinking, and to drink in groups. This pattern, in turn, leads family, physicians, and others to be more likely to suspect that a man they know is an alcoholic. Women also tend to have a greater fear that the negative implications from the stigma will reflect poorly on their families. This may also keep them from seeking help.

Implications for treatment

Research has indicated a lack of adequate training for practitioners both in problematic alcohol use in general, and in relation to women’s issues. The complexity of alcohol use disorders, particularly with gender-related issues, indicates that the need for practitioners’ knowledge, insight and compassion is enormous. Better education and awareness surrounding the gender implications of alcoholism will help care providers to adequately treat women who suffer from alcoholism. Early intervention will also increase the probability of recovery.

See also

Wikiquote has a collection of quotations related to: Alcoholism

Wikimedia Commons has media related to: Alcoholism

Alcohol consumption and health

Alcoholism in family systems

Alcohol dementia

Alcohol-related traffic crashes

Alcohol tolerance

Alcohol withdrawal syndrome

Alcoholic lung disease

Binge drinking

List of countries by alcohol consumption

Alcohol intoxication

E. Morton Jellinek

Ethanol Metabolism biochemical discussion of alcohol metabolism

Handbook on Drug and Alcohol Abuse

Hangover

List of deaths through alcohol

Substance abuse

Self-medication

Wernicke-Korsakoff syndrome

Willingway Hospital

Medical diagnostics to test for alcohol use

Blood alcohol content

Full blood count

Liver function tests

Al-Anon and Alateen: support groups for friends and families affected by alcoholism

References

^ The American Medical Association “Definitions”

^ www.dictionary.com,Definition: dipsomania

^ Glavas MM, Weinberg J (2006). “Stress, Alcohol Consumption, and the Hypothalamic-Pituitary-Adrenal Axis”. in Yehuda S, Mostofsky DI. Nutrients, Stress, and Medical Disorders. Totowa, NJ: Humana Press. pp. 165183. ISBN 978-1-58829-432-6. 

^ Agarwal-Kozlowski, K.; Agarwal, DP. (Apr 2000). “[Genetic predisposition for alcoholism]“. Ther Umsch 57 (4): 17984. PMID 10804873. 

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^ Based on information from Dr. Mark Willenbring of the National Institute on Alcohol Abuse and Alcoholism, the February 2007 issue of Newsweek – Adler, Jerry; Underwood, Anne; Kelley, Raina; Springen, Karen; Breslau, Karen. “Rehab Reality Check” Newsweek, 2/19/2007, Vol. 149 Issue 8, p44-46, 3p, 4c

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What Is Mental Illness? Schizophrenia to Bipolar Psychology

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Bipolar $16.95 Explaining bipolar in a common sense, every day language, this book shares real stories of people with bipolar and addresses the disorder from a personal, medical, drug and alcohol abuse, and forensic perspectives.

Advances in Treatment of Bipolar Disorder $62 Advances in Treatment of Bipolar Disorder is essential for today’s clinicians who want to stay abreast of the latest developments. This book offers a very timely and exciting perspective on new ways to treat bipolar disorder. Contributors review recent developments in the treatment and maintenance treatment of patients with acute mania and acute bipolar depression as well as maintenance therapy and the management of, rapid-cycling bipolar disorder, and acute bipolar depression.

Take Charge of Bipolar Disorder $9.99 The authors offer those with Bipolar Disorder a four-step plan towards managing the illness and creating lasting stability.

Bipolar II Disorder $52 Reviews our knowledge of Bipolar II Disorder, covering its history, classification, neurobiology and treatment.

The Complete Idiot’s Guide to Bipolar Disorder $15.99 Clear answers on correctly diagnosing and living with bipolar disorder. This comprehensive and reliable guide addresses how bipolar disorder is different from other disorders, the latest research into bipolar treatments, strategies for living with bipolar disorder, and much more. *Bipolar disorder is estimated to be the sixth leading cause of disability in the world, and the number of Americans diagnosed as bipolar may be as high as 10 million *Includes information on parenting a child with bipolar disorder

Handbook of Bipolar Disorder $199.95 An expert summary of our current understanding of bipolar disorder, this reference examines existing theories, treatment regimens, and clinically relevant applications by world authorities in psychiatric research. Divided into four main sections, this guide delves into the diagnosis and epidemiology of bipolar disorder and progresses to discussions of patient care, emerging management approaches, and the underlying biology of the disease.

Living with Bipolar Disorder $17.95 Living with Bipolar Disorder is designed to help patients and their families develop the skills they need to be good consumers of treatment and to become expert partners in the management of this challenging disorder. Drawing on research documenting the strength of combining drug treatments with behavioral interventions for fighting bipolar disorder, the authors of this book take a skill-based, family-and-friends approach to managing the ups and downs commonly experienced with bipolar disorder. Readers will learn how to better recognize mood shifts before they happen, minimize their impact, and move on with their lives. Family members will learn how to recognize potential problems, provide encouragement, practice new coping skills, and understand what a loved one is going through. Living with Bipolar Disorder provides worksheets and forms to help readers reinforce skills and practices learned in therapy, as well as useful information about the details of living with bipolar disorder, advice on the best ways to avoid relapses, and strategies for anticipating problems. In this new edition, the authors have expanded the text to reflect the newest advances in research on the management of bipolar disorder, adding the latest in drug information, advice on selecting a therapist, a discussion of the challenges of transitioning from adolescence to adulthood with bipolar, managing stress, improving relationship and communication skills both with the family and with one's clinician, and more. Living with Bipolar Disorder offers a wealth of effective strategies to reduce the likelihood of episodes of depression or mania and maximize the enjoyment of life.

Cognitive Dysfunction in Bipolar Disorder $55 Cognitive Dysfunction in Bipolar Disorder is the first comprehensive book of its kind. it compiles the latest data in neuropsychology, neuroimaging, neurogenetics, and functional outcomes research to enable clinicians to more effectively utilize pharmacological and psychotherapeutic techniques in their treatment of bipolar disorder.

Practical Management of Bipolar Disorder $50 Practical guide covering pharmacological and psychosocial treatments, management of bipolar disorder with a clinical perspective and insights from 'lived experience'.

Family Experiences of Bipolar Disorder $18.95 Bipolar disorder can be a devastating illness, seriously affecting not only the person with bipolar but also their children, partner, parents, family and friends. While most people are familiar with the terms 'manic depressive' and 'bipolar disorder', there remains a lack of real understanding about the illness and many sufferers and their families can feel helpless, alone and misunderstood. "Family Experiences of Bipolar Disorder" is a personal and honest account of bipolar disorder. The author Cara Aiken has lived with bipolar for 10 years, and in this book she gathers together her experiences and those of a host of contributors to portray the reality of the illness and its impact on family life. Their children give open and frank accounts of their lives with a bipolar parent, and partners and close family members explain how it has affected them. The book also features important facts and figures related to bipolar which are contributed by leading experts.This moving and insightful book will provide an invaluable source of guidance, advice and support to people with bipolar disorder and their families, as well as an insight for professionals into the reality of life with the illness.

Bipolar Disorder For Dummies $19.99 Bipolar Disorder affects many more people than just the 2.5 million Americans who suffer from the disease. Like depression and other serious illnesses, bipolar disorder also affects spouses, partners, family members, friends and coworkers. And, according to the Child and Adolescent Bipolar Foundation, 15% of children diagnosed with ADHD may actually be suffering from early-onset of Bipolar Disorder. Bipolar Disorder For Dummies reveals some of the causes and consequences of bipolar disorder, let you in on some crisis survival strategies, and describe ways that friends and family members can support loved ones who have the disease. The book includes an overview of the causes and symptoms of bipolar disorder, explains step-by-step how to obtain an accurate diagnosis, discusses the medications available, and tells what you can and can’t do to help someone with the disease. You’ll learn::; The different categories and potential causes of bipolar disorder; How to select the right mental health specialist; Managing employment-related issues brought on because of the disorder; How bipolar disorder affects children; Advocating for yourself or a loved one; Planning ahead for manic and depressive episodes; Selecting the best medications for you—including alternative “natural” treatments; How to survive an immediate crisis situation; Identifying triggers and mapping your moods. Complete with fill-in-the-blanks forms and charts, key web site and email addresses, and first-hand accounts from real people, Bipolar Disorder For Dummies gives you the latest information and self-help strategies you and your loved ones need to help everyone affected feel a whole lot better.

Cognitive Therapy for Bipolar Disorder $109.99 A thoroughly updated version of a key practitioner text, this new edition includes a treatment manual of cognitive-behavioural therapy for Bipolar Disorder which incorporates the very latest understanding of the psycho-social aspects of bipolar illness. Updated to reflect treatment packages developed by the authors over the last decade, and the successful completion of a large randomized controlled study which shows the efficacy of CBT for relapse prevention in Bipolar Disorder Demonstrates the positive results of a combined approach of cognitive behavioural therapy and medication Provides readers with a basic knowledge of bipolar disorders and its psycho-social aspects, treatments, and the authors’ model for psychological intervention Includes numerous clinical examples and case studies

Mastering Bipolar Disorder $18.14 Personal stories from sufferers of bipolar disorder reveal what it's like on the inside. Their inspiring accounts and wise advice are accompanied by tips from psychiatrists for managing this difficult condition successfully.

Voices of Bipolar Disorder $9.99 Heartbreaking and yet humorous, this inspirational collection includes personal stories from more than 40 diverse people who are living with bipolar disorder – a condition that affects some five million Americans.

Childhood Bipolar Disorder $12.95 In a time when parents are overwhelmed with baffling and often conflicting information, The Childhood Bipolar Disorder Answer Book explains confusing medical lingo and provides straightforward answers to pressing questions.

Psychoeducation Manual for Bipolar Disorder $52 This book is a pragmatic, therapists’ guide for how to implement psychoeducation for bipolar patients.

Bipolar Disorder, Second Edition $26 Family-focused psychoeducational treatment (FFT) is among a very small number of psychosocial treatments that have been found to be effective in multiple studies to improve the course of bipolar disorder. This indispensable guide describes how to implement FFT with adult and adolescent patients and their family members. Provided are practical procedures for helping families understand the nature of bipolar disorder, strengthen their communication skills, solve day-to-day problems, and reduce the risk and severity of relapse. The book incorporates state-of-the-art knowledge on the illness and its biological and psychosocial management. More than a dozen reproducible handouts are included.

Psychology Today: Taming Bipolar Disorder $14.99 Living and thriving with bipolar disorder. Bipolar disorder is about the wildest of euphorias and the deepest of depressions. Now, Alpha Books and Psychology Today present all the information, guidance, and support people with bipolar disorder-and their loved ones-need in order to thrive. This important book contains cutting-edge research and straightforward advice from the most respected names on bipolar disorder, along with the most up-to-date information on mental health organizations and support and advocacy groups. In addition, readers will find inspiring stories of courage and triumph. * More than two million Americans live with bipolar disorder-and it’s on the rise among children and adolescents * Includes strategies for navigating the health care system, nurturing relationships, advancing in the workplace, and repairing bridges burned during mania and depression * Features the latest research-from new pharmaceuticals to innovative therapies, dietary changes to acupuncture, light therapy to mood charting

Understanding Bipolar Disorder $75 This is the first book to systematically examine the development and course of bipolar disorder across the lifespan, identifying important directions for evidence-based treatment and prevention. The editors and contributors are foremost authorities who synthesize cutting-edge research at multiple levels of analysis, including genetic, neurobiological, cognitive, emotional, and family perspectives. Compelling topics include how bipolar symptoms change from childhood through adolescence and adulthood and the interplay of risk and protective factors at different developmental stages. The volume also addresses how developmental knowledge can inform the selection and timing of clinical interventions.

Advanced Mood Disorder Questionnaire (Ha-Mdq) $47.23 Used – The HIRSCHFELD ADVANCED Mood Disorder Questionnaire (HA-MDQ) Is A 29-Item, Self-Report, Patient Screening Scale For Depression And Bipolar Disorder. It Takes Five To Ten Minutes To Complete And Offers Screening Cutoff Scores For The Following Domains: Depression Bipolar Disorder: Both Current And Historical Assessment For Bipolar Depression, Bipolar Mania, And Bipolar Mixed State Substance Abuse, A Common Comorbid Condition To Mood Disorders That Often Interferes With Successful Treatment

Advanced Mood Disorder Questionnaire (Ha-Mdq) $34.77 Used – The HIRSCHFELD ADVANCED Mood Disorder Questionnaire (HA-MDQ) Is A 29-Item, Self-Report, Patient Screening Scale For Depression And Bipolar Disorder. It Takes Five To Ten Minutes To Complete And Offers Screening Cutoff Scores For The Following Domains: Depression Bipolar Disorder: Both Current And Historical Assessment For Bipolar Depression, Bipolar Mania, And Bipolar Mixed State Substance Abuse, A Common Comorbid Condition To Mood Disorders That Often Interferes With Successful Treatment

Developmental And Behavioral Pediatrics $75.01 The thoroughly updated Second Edition of this popular handbook provides practical guidance on diagnosing and treating children with developmental and behavioral problems in the primary care setting. New chapters cover pediatric psychopharmacology, sensory integrations disorder, bad news in the media, post-traumatic stress disorder, Asperger syndrome, promoting resilience, the explosive child, family treatment, cultural competence, and bipolar disorder. The authors present current information on common problems such as ADHD, biting, school avoidance, the picky eater, obesity, sleep problems, and colic and on significant developmental disorders such as autistic spectrum disorder, cerebral palsy, and the dysmorphic child. A separate section focuses on screening for developmental and behavioral disorders in primary care.

Men’s Health $0 17+~~Michael Quach~~Michael Quach~~http://itunes.apple.com/app/mens-health/id331906063?uo=5~~2009 Michael Quach~~1.0~~1974454~~525201~~http://sites.google.com/site/michaelquachapps/home/men-s-health~~http://sites.google.com/site/michaelquachapps/home/men-s-health

Mood Disorder Questionnaire $30.95 The Mood Disorder Questionnaire (MDQ) Is A 13-Item Checklist Developed By Robert M.A. Hirschfeld, M.D. The MDQ Serves As An Effective Instrument For Screening Patients Who Have A History Of A Manic Episode Associated With Bipolar Disorder.The MDQ Addresses: Manic Symptoms Patients May Have Had Number Of Symptoms Present At Any One Time Clinically Significant Distress/Impairment Across Multiple Areas Of Functioning This Brief, Easy-To-Use Screening Instrument Has Been Validated As Having Good Sensitivity.

Mood Disorder Questionnaire $21.88 Used – The Mood Disorder Questionnaire (MDQ) Is A 13-Item Checklist Developed By Robert M.A. Hirschfeld, M.D. The MDQ Serves As An Effective Instrument For Screening Patients Who Have A History Of A Manic Episode Associated With Bipolar Disorder.The MDQ Addresses: Manic Symptoms Patients May Have Had Number Of Symptoms Present At Any One Time Clinically Significant Distress/Impairment Across Multiple Areas Of Functioning This Brief, Easy-To-Use Screening Instrument Has Been Validated As Having G

Mood Disorder Questionnaire $27.38 Used – The Mood Disorder Questionnaire (MDQ) Is A 13-Item Checklist Developed By Robert M.A. Hirschfeld, M.D. The MDQ Serves As An Effective Instrument For Screening Patients Who Have A History Of A Manic Episode Associated With Bipolar Disorder.The MDQ Addresses: Manic Symptoms Patients May Have Had Number Of Symptoms Present At Any One Time Clinically Significant Distress/Impairment Across Multiple Areas Of Functioning This Brief, Easy-To-Use Screening Instrument Has Been Validated As Having G

Treating Bipolar Disorder: A Clinician’s Guide to Interpersonal and Social Rhythm Therapy $58.64 New – This innovative manual presents a powerful approach for helping people manage bipolar illness and protect against the recurrence of manic or depressive episodes. Interpersonal and social rhythm therapy focuses on stabilizing moods by improving medication adherence, building coping skills and relationship satisfaction, and shoring up the regularity of daily rhythms or routines. Each phase of this flexible, evidence-based treatment is vividly detailed, from screening, assessment, and case co

Treating Bipolar Disorder: A Clinician’s Guide to Interpersonal and Social Rhythm Therapy $21.04 Used – This innovative manual presents a powerful approach for helping people manage bipolar illness and protect against the recurrence of manic or depressive episodes. Interpersonal and social rhythm therapy focuses on stabilizing moods by improving medication adherence, building coping skills and relationship satisfaction, and shoring up the regularity of daily rhythms or routines. Each phase of this flexible, evidence-based treatment is vividly detailed, from screening, assessment, and case c

Treating Bipolar Disorder: A Clinician’s Guide to Interpersonal and Social Rhythm Therapy $42.45 New – This innovative manual presents a powerful approach for helping people manage bipolar illness and protect against the recurrence of manic or depressive episodes. Interpersonal and social rhythm therapy focuses on stabilizing moods by improving medication adherence, building coping skills and relationship satisfaction, and shoring up the regularity of daily rhythms or routines. Each phase of this flexible, evidence-based treatment is vividly detailed, from screening, assessment, and case co

Treating Bipolar Disorder: A Clinician’s Guide to Interpersonal and Social Rhythm Therapy $17.9 Used – This innovative manual presents a powerful approach for helping people manage bipolar illness and protect against the recurrence of manic or depressive episodes. Interpersonal and social rhythm therapy focuses on stabilizing moods by improving medication adherence, building coping skills and relationship satisfaction, and shoring up the regularity of daily rhythms or routines. Each phase of this flexible, evidence-based treatment is vividly detailed, from screening, assessment, and case c